In addition, urolithiasis is associated with AUTF in a substantial percentage of noninstrumented VU specimens.Ītypical urine cytology bladder cancer high-grade urothelial carcinoma urine urothelial carcinoma urothelial neoplasia. In particular, the rate of high-grade urothelial carcinoma is significantly higher in noninstrumented VU specimens containing AUTF than those containing BUTF (8.8% vs 0.7% P<.0001). The authors previously analyzed the outcome of patients with benign-appearing UTF in 274 noninstrumented VU specimens. If UTF contain cytomorphologically atypical cells, the diagnosis often becomes more challenging. The presence of AUTF in noninstrumented VU is associated with low rates of urothelial neoplasia but a statistically higher risk of urothelial neoplasia than the presence of BUTF (10.0% vs 4.4% P<.05). BACKGROUND: The interpretation of urothelial tissue fragments (UTF) in voided urine (VU) specimens is controversial. Of 72 cases without histopathologic, radiologic, or cytopathologic follow-up, 62 (86.1%) had a mean clinical follow-up of 22.5 months and 10 cases did not have clinical follow-up. More importantly, however, they are sometimes seen in patients who have acute renal failure. Twenty-five cases had follow-up cytology specimens, all of which were negative for malignancy. Hi Well, atypical cell fragments can actually be seen in a number of cases- for one, they are sometimes seen in recently catheterised patients- the procedure of placing the catheter can cause some trauma to the epithelial cells (urothelial) of the urethra, breaking them up. A total of 49 specimens (28.8%) were diagnosed with urolithiasis on follow-up. Twenty-four specimens had subsequent or coincidental surgical pathology specimens with the following overall rates of neoplasia: high-grade urothelial carcinoma: 8.8% (15 specimens), low-grade urothelial neoplasia: 1.2% (2 specimens), and prostate carcinoma invading the bladder: 0.6% (1 specimen). The Johns Hopkins Hospital electronic pathology database was searched for VU cases containing UTF over a 5-year period.Ī total of 170 noninstrumented VU specimens containing AUTF were identified. BACKGROUND The presence of urothelial tissue fragments (UTF) in voided urine (VU) is often considered an abnormal finding that may be associated with the presence of urothelial papillary neoplasms. In this retrospective study, noninstrumented VU specimens containing UTF with atypical cytomorphological features (AUTF) were evaluated and compared with the previous results. According to LiveStrong, the sediment that is present in urine is made up of debris, cells and other solid materials. The interpretation of urothelial tissue fragments (UTF) in voided urine (VU) specimens is controversial.
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